New research study recommends the ketogenic or keto diet plan may prove useful in assisting treat some kinds of cancer by improving the efficacy of chemotherapy and other drugs.
The key to success is keeping blood glucose under control. The keto diet plan does simply that by restricting carbs to a minimum.
It includes high fat foods and likewise consists of foods with an appropriate amount of protein and a really low amount of carbohydrates. Glucose is obtained from sugar that exists in carbs.
The way the keto diet works and the reason it's being thought about as part of a therapy to treat some kinds of cancer, is that it deprives the body of glucose. This glucose deprivation induces a state called "ketosis.".
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In ketosis, the body is forced to use stored fat in the kidneys rather of sugar to produce an alternative source of energy.
A brand-new research study explores the keto diet as a potential opportunity for treatment of particular types of cancer. A group of scientists from the University of Texas at Dallas restricted the levels of circulating glucose in mice by feeding them a ketogenic diet plan and administering a diabetes drug that stops the reabsorption of blood sugar in the kidneys.
The scientists published their paper in the journal Cell Reports. An assistant professor of biological sciences at the University of Texas at Dallas, Jung-Whan Kim, is the matching author AlkaTone of the new research study while Meng-Hsiung Hsieh is the very first author.
Formerly, a cancer type called squamous cell carcinoma (SCC) relies heavily on glucose to sustain its "antioxidative capability and survival" compared to other types of cancers, according to Kim and his group.
The team reasoned limiting glucose must make SCC more vulnerable to treatment. To check this theory, they fed mice with xenograft growths with either a ketogenic diet plan including 0.1% carbohydrates or a regular diet.
" Xenograft tumor growth of lung SCC [...] and esophageal SCC [...] was considerably inhibited upon ketogenic diet plan as compared to normal chow fed groups," said the research study.
Kim noted that both the ketogenic diet and the medicinal limitation of blood glucose on their own hindered the more growth of SCC growths in mice with lung cancer. On the other hand, the glucose restriction did not affect non-SCC growths.
" While these interventions did not diminish the growths, they did keep them from progressing, which suggests this type of cancer might be vulnerable to glucose limitation.".
Kim said their results recommend this approach is "cancer cell type specific. We can not generalize to all types of cancer.".
Kim said the crucial finding of their new study in mice is that a ketogenic diet plan alone does have some tumor growth repressive impact in SCC. However when the group integrated this with a diabetes drug and chemotherapy, the therapy was even more effective.
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